Mouse VSTM3 Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Mouse VSTM3 Protein, His Tag

Mouse VSTM3 Protein, His Tag

产品编号

KMP2342

别名

具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9
Catalog Number	KMP2342
Product Description	The Mouse VSTM3 Protein(KMP2342) is produced in HEK293 Cells and the target gene encoding Gly26-Phe135 is expressed with a 6His tag at the C-terminus.
Molecular Name	VSTM3
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	T cell immunoreceptor with Ig and ITIM domains(TIGIT), also called WUCAM, VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif(ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells(DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113(PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
Predicted Molecular Weight	12.76 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P86176
Function	Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0