Mouse CD80 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD80 Protein, His Tag

Mouse CD80 Protein, His Tag

产品编号

KMP2333

别名

T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T淋巴细胞活化抗原CD80, T-lymphocyte activation antigen CD80, Activation B7-1 antigen
Catalog Number	KMP2333
Product Description	The Mouse CD80 Protein(KMP2333) is produced in HEK293 Cells and the target gene encoding Val38-Asn246 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD80
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. Mouse CD80 consists of an extracellular domain(ECD) with twoimmunoglobulin-like domains, transmembrane segment, and cytoplasmic domain. B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA4, constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response.
SDS-PAGE
Predicted Molecular Weight	24.63 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q00609
Function	Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

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