Mouse VTCN1 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Mouse VTCN1 Protein, Fc Tag

Mouse VTCN1 Protein, Fc Tag

产品编号

KMP2324

别名

含 V 组结构域的 T 细胞激活抑制剂 1, T cell costimulatory molecule B7x, VTCN1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	含 V 组结构域的 T 细胞激活抑制剂 1, T cell costimulatory molecule B7x, VTCN1
Catalog Number	KMP2324
Product Description	The Mouse VTCN1 Protein(KMP2324) is produced in HEK293 Cells and the target gene encoding Leu25-Ser256 is expressed with a Fc tag at the C-terminus.
Molecular Name	VTCN1
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse V-set domain-containing T-cell activation inhibitor 1/VTCN1/B7-H4 is glycosylated member of the B7 family of immune co-stimulatory proteins. B7-H4 consists of extracellular domain(ECD) with one Ig-like V-set domain and one Ig-like C2-set domain. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. It also involved in promoting epithelial cell transformation.
Predicted Molecular Weight	25.56 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q7TSP5
References	1.Immunity 18:849-861 (2003) 2.Immunity 18:863-873 (2003) 3.Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392 (2003)
Function	Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.

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