Mouse CD155 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CD155 Protein, His Tag

Mouse CD155 Protein, His Tag

产品编号

KMP2320

别名

重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155
Catalog Number	KMP2320
Product Description	The Mouse CD155 Protein(KMP2320) is produced in HEK293 Cells and the target gene encoding Asp29-Leu348 is expressed with a 6His tag at the C-terminus.
Molecular Name	CD155
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse poliovirus receptor(PVR, CD155) is a type I transmembrane(TM) glycoprotein that is a member of the nectin-related family of adhesion proteins within the immunoglobulin superfamily. It binds other molecules including vitronectin, Nectin3, DNAM1, CD96, and TIGIT, but does not bind homotypically. CD155 includes a 28 aa signal sequence, a 318 aa extracellular domain(ECD) with one N-terminal V-type and two C2-type Ig-like domains, a 24 aa TM segment and a 38 aa cytoplasmic tail. Epithelial, endothelial, and many immune cells show low CD155 expression. It is up-regulated on endothelia by IFNγ, and is highly expressed on immature thymocytes, lymph node dendritic cells, and tumor cells of epithelial and neuronal origin. On migrating cells, it is concentrated at the leading edge, where it binds basement membrane vitronectin, recruits Nectin-3-expressing cells, and cooperates with PDGF and integrin αvβ3 to promote cell migration. Binding of monocyte DNAM-1 to endothelial cell CD155 promotes transendothelial migration. Enhanced CD155 expression in tumor cells contributes to loss of contact inhibition and increased migration, but also allows tumor cell recognition and killing by DNAM-1or CD96 expressing NK cells.
SDS-PAGE
Predicted Molecular Weight	35.59 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q91WP1

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