Cynomolgus HAVCR2 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Cynomolgus HAVCR2 Protein, Fc Tag

Cynomolgus HAVCR2 Protein, Fc Tag

产品编号

KMP2310

别名

甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	甲型肝炎病毒细胞受体 2, Hepatitis A virus cellular receptor 2, HAVCR2
Catalog Number	KMP2310
Product Description	The Cynomolgus HAVCR2 Protein(KMP2310) is produced in HEK293 Cells and the target gene encoding Ser22-Arg201 is expressed with a Fc tag at the C-terminus.
Molecular Name	HAVCR2
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid(aa)extracellular domain(ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells(macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells(Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.
SDS-PAGE
Predicted Molecular Weight	19.8 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	G7P6Q7

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