Human CD226 Protein, Fc Tag_天津卡梅德科技发展有限公司

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Human CD226 Protein, Fc Tag

Human CD226 Protein, Fc Tag

产品编号

KMP2307

别名

白细胞分化抗原, CD226 antigen, CD226

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞分化抗原, CD226 antigen, CD226
Catalog Number	KMP2307
Product Description	The Human CD226 Protein(KMP2307) is produced in HEK293 Cells and the target gene encoding Glu19-Asn247 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD226
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Human DNAX accessory molecule 1(DNAM-1/CD226) is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily. Mature human DNAM-1 contains an extracellular domain(ECD) with two Ig-like C2-set domains and a cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins. DNAM-1 is expressed on multiple lymphoid and myeloid cells and interacts with CD155 and CD112. Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells, dendritic cell maturation, megakaryocyte and activated platelet adhesion to vascular endothelial cells, and monocyte extravasation; it inhibits the forrmation of osteoclasts. Plateletendothelium, interactions mediated by DNAM-1, enable the metastasis of tumor cells to the lung.
SDS-PAGE
Predicted Molecular Weight	26.01 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q15762
References	1.J. Exp. Med. 213:167-176 (2016) 2.Immunity 4:573-581 (1996)
Function	Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

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