Human CD155 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD155 Protein, mFc Tag

Human CD155 Protein, mFc Tag

产品编号

KMP2282

别名

重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155
Catalog Number	KMP2282
Product Description	The Human CD155 Protein(KMP2282) is produced in HEK293 Cells and the target gene encoding Trp21-Asn343 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD155
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Poliovirus Receptor(PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like(Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus(PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms(α, β, γ, and δ) with identical extracellular domains.
SDS-PAGE
Predicted Molecular Weight	35.08 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P15151
References	1.BMC Cancer 4:73-73 (2004) 2.Mol. Immunol. 42:463-469 (2005) 3.Cell 56:855-865 (1989) 4.Science 280:1618-1620 (1998) 5.Nat. Immunol. 6:181-188 (2005)
Function	Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport. (Microbial infection) Acts as a receptor for Pseudorabies virus. (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells.

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