Human CD258 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD258 Protein, mFc Tag

Human CD258 Protein, mFc Tag

产品编号

KMP2281

别名

肿瘤坏死因子配体超家族成员 14, Tumor necrosis factor ligand superfamily member 14, CD258

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	肿瘤坏死因子配体超家族成员 14, Tumor necrosis factor ligand superfamily member 14, CD258
Catalog Number	KMP2281
Product Description	The Human CD258 Protein(KMP2281) is produced in HEK293 Cells and the target gene encoding Ile84-Val240 is expressed with a mFc tag at the N-terminus.
Molecular Name	CD258
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumor necrosis factor(TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand(HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Predicted Molecular Weight	17.17 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	O43557
References	1.J. Immunol. 164:4105-4110 (2000) 2.Immunity 8:21-30 (1998)
Function	Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, PubMed:10754304). Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production (PubMed:10754304).

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