Human ILT3 Protein, His Tag_天津卡梅德科技发展有限公司

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Human ILT3 Protein, His Tag

Human ILT3 Protein, His Tag

产品编号

KMP2280

别名

白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, ILT3

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞免疫球蛋白样受体 B 亚家族成员 4, Leukocyte immunoglobulin-like receptor subfamily B member 4, ILT3
Catalog Number	KMP2280
Product Description	The Human ILT3 Protein(KMP2280) is produced in HEK293 Cells and the target gene encoding Gln22-Glu259 is expressed with a 6His tag at the C-terminus.
Molecular Name	ILT3
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Mouse Leukocyte Immunoglobulin-like Receptor Subfamily B Member 4(LILRB4/CD85k/ILT3) is an approximately transmembrane glycoprotein that negatively regulates immune cell activation. Mouse LILRB4 consists of a 215 amino acid(aa) extracellular domain with two Ig-like domains, a 22 aa transmembrane segment, and a 75 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs(ITIM). Within the ECD, mouse LILRB4 shares 45% and 77% aa sequence identity with human and rat LILRB4, respectively. Alternative splicing of mouse LILRB4 generates a potentially soluble isoform that lacks the transmembrane segment. LILRB4 is expressed on dendritic cells(DC), monocytes, macrophages, and vascular endothelial cells(EC). Ligation of LILRB4 triggers ITIM-mediated inhibition of cellactivating signaling, leading to enhanced immune tolerance and reduced allogeneic graft rejection. Soluble LILRB4 induces the differentiation of CD8+ T suppressor cells(Ts) that can inhibit the effector functions of CD4+ Th cells and CD8+ CTL. In turn, CD8+ Ts cells induce LILRB4 up-regulation and a tolerogenic phenotype in monocytes, DC, and EC.
SDS-PAGE
Predicted Molecular Weight	27.15 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	A0A0A0MS20#structure

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