Human Biotinylated ROR1 Protein, His Tag, Avi Tag_天津卡梅德科技发展有限公司

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Human Biotinylated ROR1 Protein, His Tag, Avi Tag

Human Biotinylated ROR1 Protein, His Tag, Avi Tag

产品编号

KMP2275

别名

受体酪氨酸激酶样孤儿受体, Inactive tyrosine-protein kinase transmembrane receptor ROR1, ROR1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	受体酪氨酸激酶样孤儿受体, Inactive tyrosine-protein kinase transmembrane receptor ROR1, ROR1
Catalog Number	KMP2275
Product Description	The Human Biotinylated ROR1 Protein(KMP2275) is produced in HEK293 Cells and the target gene encoding Gln30-Glu403 is expressed with a 6His, Avi tag at the C-terminus.
Molecular Name	ROR1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Receptor tyrosine kinase-like orphan receptor 1(ROR1), also known as neurotrophic tyrosine kinase, it is a member of the ROR family within receptor tyrosine kinases(RTK) superfamily. Human ROR1 is a type I transmembrane protein with 937 amino acids(aa) in length. It contains a 29 aa signal sequence, a 377 aa extracellular domain(ECD), a 21 aa transmembrane segment, and a 510 aa cytoplasmic region. ROR1 expressed strongly in human heart, lung and kidney, but weakly in the CNS. At developmental stage, it expressed at high levels during early embryonic development. ROR1 has been shown to have very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. It may act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
SDS-PAGE
Predicted Molecular Weight	42.82 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q01973
References	1.PLoS ONE 9:E102695-E102695 (2014) 2.Proc. Natl. Acad. Sci. U.S.A. 113:5993-5998 (2016)
Function	Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

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