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Cynomolgus TNFSF18 Protein, His Tag

Cynomolgus TNFSF18 Protein, His Tag

产品编号

KMP2266

别名

肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias肿瘤坏死因子配体超家族成员 18, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor ligand superfamily member 18, TNFSF18
Catalog NumberKMP2266
Product DescriptionThe Cynomolgus TNFSF18 Protein(KMP2266) is produced in HEK293 Cells and the target gene encoding Glu74-Ser199 is expressed with a 6His tag at the C-terminus.
Molecular NameTNFSF18
SpeciesCynomolgus
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundTNFSF18 is a single-pass type II membrane protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 cytokine binds to TNFRSF18/AITR/GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
SDS-PAGE
Predicted Molecular Weight14.52 kDa
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot IDA0A2K5UCD9

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