Human Biotinylated FGL1 Protein, Avi Tag, His Tag_天津卡梅德科技发展有限公司

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Human Biotinylated FGL1 Protein, Avi Tag, His Tag

Human Biotinylated FGL1 Protein, Avi Tag, His Tag

产品编号

KMP2253

别名

纤维蛋白原样 1, Fibrinogen-like protein 1, FGL1

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	纤维蛋白原样 1, Fibrinogen-like protein 1, FGL1
Catalog Number	KMP2253
Product Description	The Human Biotinylated FGL1 Protein(KMP2253) is produced in HEK293 Cells and the target gene encoding Leu23-Ile312 is expressed with a AVI, 6His tag at the C-terminus.
Molecular Name	FGL1
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, 2mM EDTA, pH8.0
Background	Fibrinogen-like protein 1(FGL1) is also known as HP-041, Hepassocin, HFREP-1, LFIRE-1, is a liver-specific secreted protein belonging to the fibronogen superfamily, whose members share a fibrinogen domain at their C-termini. It is secreted by the liver and functions as a mitogen for hepatocytes. Hepassocin may play a role in the development of hepatocellular carcinomas. Hepassocin is a disulfide-linked homodimeric protein with a C-terminal fibrinogen domain. It is reported that it is a major immune inhibitory ligand of LAG-3.
SDS-PAGE
Predicted Molecular Weight	34.84 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q08830
References	1.Biochim. Biophys. Acta 1520:45-53 (2001) 2.Gut 59:817-826 (2010) 3.Cell 0:0-0 (2018)
Function	Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a major ligand of LAG3 (PubMed:30580966). Responsible for LAG3 T-cell inhibitory function (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967).

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