Human CD3E Protein, mFc Tag_天津卡梅德科技发展有限公司

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Human CD3E Protein, mFc Tag

Human CD3E Protein, mFc Tag

产品编号

KMP2249

别名

T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, CD3E

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	T细胞表面糖蛋白CD3ε链, T-Cell Surface Glycoprotein CD3 Epsilon Chain, CD3E
Catalog Number	KMP2249
Product Description	The Human CD3E Protein(KMP2249) is produced in HEK293 Cells and the target gene encoding Gln22-Thr48 is expressed with a mFc tag at the C-terminus.
Molecular Name	CD3E
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	T-Cell Surface Glycoprotein CD3 ε Chain(CD3ε) is a single-pass type I membrane protein. CD3ε contains 1 Ig-like(immunoglobulin-like) domain and 1 ITAM domain. CD3ε is a polypeptide encoded by the CD3E gene on chromosome 11 in humans. The T cell receptor-CD3 complex(TCR/CD3 complex) is involved in T-cell development and several intracellular signal-transduction pathways. This complex is critical for T-cell development and function, and represents one of the most complex transmembrane receptors. The T cell receptor-CD3 complex is unique in having ten cytoplasmic immunoreceptor tyrosine-based activation motifs(ITAMs). TCR/CD3 complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways.
Predicted Molecular Weight	2.84 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P07766
References	1.J. Immunol. 163:25-31 (1999) 2.J. Immunol. 173:2262-2270 (2004) 3.J. Clin. Invest. 114:1512-1517 (2004) 4.Proc. Natl. Acad. Sci. U.S.A. 86:3277-3281 (1989) 5.Int. Immunol. 28:127-137 (2016) 6.Nat. Genet. 3:77-81 (1993)
Function	Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095, PubMed:26507128).

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