Human TNFRSF17 Protein, His Tag, Flag Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Human TNFRSF17 Protein, His Tag, Flag Tag

Human TNFRSF17 Protein, His Tag, Flag Tag

产品编号

KMP2243

别名

B细胞成熟抗原, CD269, BCMA

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	B细胞成熟抗原, CD269, BCMA
Catalog Number	KMP2243
Product Description	The Human TNFRSF17 Protein(KMP2243) is produced in HEK293 Cells and the target gene encoding Met1-Ala54 is expressed with a 6His, Flag tag at the N-terminus.
Molecular Name	TNFRSF17
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B cell maturation antigen(BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid(aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development,function and regulation.
SDS-PAGE
Predicted Molecular Weight	6.9 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	Q02223
References	1.Nature 404:995-999 (2000) 2.J. Immunol. 165:1322-1330 (2000) 3.Nat. Immunol. 1:252-256 (2000)
Function	Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0