Rhesus EpCAM Protein_天津卡梅德科技发展有限公司

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Rhesus EpCAM Protein

Rhesus EpCAM Protein

产品编号

KMP4354

别名

上皮细胞粘附分子, EpCAM Protein, Rhesus EpCAM Protein

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	上皮细胞粘附分子, EpCAM Protein, Rhesus EpCAM Protein
Catalog Number	KMP4354
Product Description	The Rhesus EpCAM Protein(KMP4354) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus EPCAM [(Identical to the Rhesus EPCAM (NP_001035118.1)] (Met1-Lys265) is expressed with five amino acids (DDDDK) at the C-terminus. Cynomolgus and Rhesus EPCAM sequences are identical.
Molecular Name	EpCAM
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type I transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	28 kDa

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