Rhesus ICOS Protein, hFc Tag_天津卡梅德科技发展有限公司

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Rhesus ICOS Protein, hFc Tag

Rhesus ICOS Protein, hFc Tag

产品编号

KMP4333

别名

诱导T细胞共刺激分子, ICOS Protein, Rhesus ICOS Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	诱导T细胞共刺激分子, ICOS Protein, Rhesus ICOS Protein, hFc Tag
Catalog Number	KMP4333
Product Description	The Rhesus ICOS Protein(KMP4333) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus ICOS (NP_001253918.1) (Met1-Lys140) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	ICOS
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Inducible costimulator (ICOS), also called AILIM (Activation-Inducible Lymphocyte Immunomediatory Molecule) is a cell-surface receptor and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4, and PD-1. The interaction of B7-H2/ICOS plays a critical role in Th cell differentiation, T−B cell interactions which are essential for the germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. Also, ICOS is more potent in the induction of IL-10 production, a cytokine important for the suppressive function of T regulatory cells. The B7-1/B7-2--CD28/CTLA-4 and ICOS-B7RP-1 pathway provide key second signals that can regulate the activation, inhibition, and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1/B7-2-CD28/CTLA-4 and ICOS-B7RP-1 pathway has been suggested as being involved in the development of airway inflammation and airway hyperresponsiveness.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	42.7 kDa

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