Rhesus CDCP1 Protein, His Tag_天津卡梅德科技发展有限公司

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Rhesus CDCP1 Protein, His Tag

Rhesus CDCP1 Protein, His Tag

产品编号

KMP4327

别名

含CUB域蛋白1, CDCP1 Protein, Rhesus CDCP1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	含CUB域蛋白1, CDCP1 Protein, Rhesus CDCP1 Protein, His Tag
Catalog Number	KMP4327
Product Description	The Rhesus CDCP1 Protein(KMP4327) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus CDCP1 (XP_001114659.1) (Met1-Thr667) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	CDCP1
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT-SP1. It also interacts with SRC and PRKCG/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF/EGFR-induced cell migration. It has been shown that signaling via EGF/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	73.4 kDa

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