Rhesus L-selectin Protein, His Tag_天津卡梅德科技发展有限公司

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Rhesus L-selectin Protein, His Tag

Rhesus L-selectin Protein, His Tag

产品编号

KMP4309

别名

选择素L, L-selectin Protein, Rhesus L-selectin Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	选择素L, L-selectin Protein, Rhesus L-selectin Protein, His Tag
Catalog Number	KMP4309
Product Description	The Rhesus L-selectin Protein(KMP4309) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus SELL (Met1-Asn332) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	L-selectin
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	35.6 kDa

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