Rhesus ALK4 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Rhesus ALK4 Protein, hFc Tag

Rhesus ALK4 Protein, hFc Tag

产品编号

KMP4291

别名

激活素受体 1B 型, ALK4 Protein, Rhesus ALK4 Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	激活素受体 1B 型, ALK4 Protein, Rhesus ALK4 Protein, hFc Tag
Catalog Number	KMP4291
Product Description	The Rhesus ALK4 Protein(KMP4291) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus ACVR1B (NP_001252559.1) (Met1-Glu126) is expressed, fused with the Fc region of human IgG1 at the C-terminus.
Molecular Name	ALK4
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	ALK-4 (Activin Receptor-Like Kinase 4) or ACVR1B (Activin A Receptor, type 1B), belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family, and TGFB receptor subfamily. ALK-4/ACVR1B acts as a transducer of activin or activin like ligands signals. Activin binds to either ACVR2A or ACVR2B and then forms a complex with ACVR1B. The known type II activin receptors include ActRII and ActRIIB, while the main type I activin receptor in mammalian cells is ALK-4 (ActRIB). In the presence of activin, type II and type I receptors form complexes whereby the type II receptors activate ALK-4 through phosphorylation. The activated ALK-4, in turn, transduces signals downstream by phosphorylation of its effectors, such as Smads, to regulate gene expression and affect cellular phenotype. ALK-4/ACVR1B is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	38.2 kDa

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