Rhesus TGF beta 2 Protein, His Tag_天津卡梅德科技发展有限公司

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Rhesus TGF beta 2 Protein, His Tag

Rhesus TGF beta 2 Protein, His Tag

产品编号

KMP4289

别名

转化生长因子β2, TGF beta 2 Protein, Rhesus TGF beta 2 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	转化生长因子β2, TGF beta 2 Protein, Rhesus TGF beta 2 Protein, His Tag
Catalog Number	KMP4289
Product Description	The Rhesus TGF beta 2 Protein(KMP4289) is produced in HEK293 Cells. A DNA sequence encoding the Rhesus TGFB2 (NP_001253447.1) (Met1-Ser414) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	TGF beta 2
Species	Rhesus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, angiogenesis, and proliferation. TGF beta 2 suppression is a promising therapeutic approach for malignant tumor therapy. The signaling pathway of TGF beta 2/Smad plays an important role in the pathological process in posterior capsule opacification (PCO) after cataract surgery. Silencing Smad2 and Smad3 efficiently blocked the effect of TGF beta 2 on cell proliferation, migration, and extracellular matrix production. TGF beta 2 activation of MEKK3/ERK1/2/5 signaling modulates Has2 expression and hyaluronan (HA) production leading to the induction of epithelial to mesenchymal transformation (EMT) events. Besides, the upregulation of the TGF beta 2 level is a common pathological feature of Alzheimer's disease (AD) brains and suggests that it may be closely linked to the development of neuronal death related to AD.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	47 kDa

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