Rat PRSS8 Protein, His Tag_天津卡梅德科技发展有限公司

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Rat PRSS8 Protein, His Tag

Rat PRSS8 Protein, His Tag

产品编号

KMP4268

别名

丝氨酸蛋白酶8, PRSS8 Protein, Rat PRSS8 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	丝氨酸蛋白酶8, PRSS8 Protein, Rat PRSS8 Protein, His Tag
Catalog Number	KMP4268
Product Description	The Rat PRSS8 Protein(KMP4268) is produced in HEK293 Cells. A DNA sequence encoding the rat Prss8 (NP_620191.1) (Met1-Arg322) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	PRSS8
Species	Rat
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Prostasin (Prss8), also known as channel activating protease 1 (CAP1), is a trypsinlike serine peptidase, and plays important roles in epithelial physiology. It is originally purified as an active, soluble enzyme from human seminal fluid and is highly expressed in prostate, lung, kidney, salivary gland and pancreas. Prostasin is expressed as a glycosyl-phosphatidylinositol (GPI)-anchored membrane protein in prostate epithelial cells, and also exists as a secreted proteolytic enzyme possibly via tryptic cleavage of its COOH-terminal hydrophobic domain. Prostasin is found to activate the epithelial sodium channel (ENaC) which is tightly regulated and is critical for maintaining salt and fluid balance in the lung and kidney in both normal and pathological conditions. Accordingly, prostasin has been proposed as a target for therapeutic inhibition in cystic fibrosis. Besides, prostasin inhibits prostate and breast cancer cell invasion in vitro, suggesting a functional role as a suppressor of tumor invasion, as well as a regulator of gene expression during inflammation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	32.9 kDa

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