Rat B7-H4 Protein, His Tag_天津卡梅德科技发展有限公司

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Rat B7-H4 Protein, His Tag

Rat B7-H4 Protein, His Tag

产品编号

KMP4261

别名

含 V 组结构域的 T 细胞激活抑制剂1, B7-H4 Protein, Rat B7-H4 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	含 V 组结构域的 T 细胞激活抑制剂1, B7-H4 Protein, Rat B7-H4 Protein, His Tag
Catalog Number	KMP4261
Product Description	The Rat B7-H4 Protein(KMP4261) is produced in HEK293 Cells. A DNA sequence encoding the rat Vtcn1 (NP_001019415.1) (Phe29-Ser256) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	B7-H4
Species	Rat
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X/VTCN1/B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X/VTCN1/B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X/VTCN1/B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	26.6 kDa

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