Rat Coagulation Factor II Protein, His Tag_天津卡梅德科技发展有限公司

>>

>>

>>

>

Rat Coagulation Factor II Protein, His Tag

Rat Coagulation Factor II Protein, His Tag

产品编号

KMP4254

别名

凝血因子II, Coagulation Factor II Protein, Rat Coagulation Factor II Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	凝血因子II, Coagulation Factor II Protein, Rat Coagulation Factor II Protein, His Tag
Catalog Number	KMP4254
Product Description	The Rat Coagulation Factor II Protein(KMP4254) is produced in HEK293 Cells. A DNA sequence encoding the rat F2 (NP_075213.2) (Met1-Arg617) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	Coagulation Factor II
Species	Rat
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Coagulation Factor II Protein (FII, F2 Protein or Prothrombin) is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. Coagulation Factor II Protein (FII, F2 Protein) also plays a role in maintaining vascular integrity during development and postnatal life. Prothrombin/Coagulation Factor II is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin/Coagulation Factor II and factor Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. Prothrombin/Coagulation Factor II is expressed by the liver and secreted in plasma. Defects in prothrombin/Coagulation Factor II are the cause of factor II deficiency (FA2D). It is very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Defects in Coagulation Factor II are also a cause of susceptibility to thrombosis. It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	69.5 kDa

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0