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Rat IL-6 Protein

Rat IL-6 Protein

产品编号

KMP4197

别名

白细胞介素-6, IL-6 Protein, Rat IL-6 Protein

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias白细胞介素-6, IL-6 Protein, Rat IL-6 Protein
Catalog NumberKMP4197
Product DescriptionThe Rat IL-6 Protein(KMP4197) is produced in E. coli. A DNA sequence encoding the rat IL6 (NP_036721.1)(Phe25-Thr211) is expressed and purified with an initial Met.
Molecular NameIL-6
SpeciesRat
HostE. coli
Size50ug, 100ug, 200ug
Purity>85% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
Formulation40% Acetonitrile, 0.1% TFA
BackgroundInterleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight21.9 kDa

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