Rabbit IL-18RAP Protein, His Tag_天津卡梅德科技发展有限公司

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Rabbit IL-18RAP Protein, His Tag

Rabbit IL-18RAP Protein, His Tag

产品编号

KMP4176

别名

白细胞介素18受体辅助蛋白, IL-18RAP Protein, Rabbit IL-18RAP Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素18受体辅助蛋白, IL-18RAP Protein, Rabbit IL-18RAP Protein, His Tag
Catalog Number	KMP4176
Product Description	The Rabbit IL-18RAP Protein(KMP4176) is produced in HEK293 Cells. A DNA sequence encoding the Rabbit IL18RAP (G1SQ92) (Met1-Val357) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	IL-18RAP
Species	Rabbit
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	40.22 kDa

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