Mouse NKG2D Protein, hFc Tag
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产品编号
KMP4107
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别名
杀伤细胞类凝集素受体K亚家族成员1, NKG2D Protein, Mouse NKG2D Protein, hFc Tag
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规格
- 50ug
- 100ug
- 200ug
Alias | 杀伤细胞类凝集素受体K亚家族成员1, NKG2D Protein, Mouse NKG2D Protein, hFc Tag |
Catalog Number | KMP4107 |
Product Description | The Mouse NKG2D Protein(KMP4107) is produced in Insect Cells. A DNA sequence encoding the Mouse KLRK1 (NP_001076791.1) (Phe77-Val219) is expressed with the Fc region of human IgG1 at the N-terminus. |
Molecular Name | NKG2D |
Species | Mouse |
Host | Insect Cells |
Size | 50ug, 100ug, 200ug |
Purity | >90% as determined by SDS-PAGE |
Purification | Affinity purification |
Endotoxin | <1.0 EU/ug determined by the LAL method |
Formulation | 20mM Tris, 250mM NaCl, 10% Glycerol, pH8.0 |
Background | KLRK1 (Killer Cell Lectin Like Receptor K1) is a Protein Coding gene. NKG2D, also known as CD314, is an immune receptor that consists of two disulfide-linked type II transmembrane proteins with short intracellular proteins incapable to transduce signals. To transduce signals, NKG2D needs adaptor proteins and it uses two adaptor proteins, DAP10 and DAP12. These two adaptor proteins associate as homodimers to NKG2D- therefore the entire receptor complex appears as a hexamer. NKG2D can send co-stimulatory signals to activate CD8 T cells. NKG2D also plays an important role in viral control. Cellular stress can induce ligands for NKG2D which results in the cell susceptible to NK cell-mediated lysis. |
Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
Molecular Weight | 44.9 kDa |