Mouse TPP1 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse TPP1 Protein, His Tag

Mouse TPP1 Protein, His Tag

产品编号

KMP4072

别名

三肽基肽酶1, TPP1 Protein, Mouse TPP1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	三肽基肽酶1, TPP1 Protein, Mouse TPP1 Protein, His Tag
Catalog Number	KMP4072
Product Description	The Mouse TPP1 Protein(KMP4072) is produced in Insect Cells. A DNA sequence encoding the Mouse TPP1 (NP_034036.1) (Met1-Pro562) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	TPP1
Species	Mouse
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 150mM NaCl, 10% Glycerol, pH7.5
Background	Tripeptidyl-peptidase 1 (TPP1/CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. TPP1/CLN2 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Defects in TPP1/CLN2 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2), a form of neuronal ceroid lipofuscinosis which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	60.9 kDa

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