Mouse Hsp90 alpha Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse Hsp90 alpha Protein, His Tag

Mouse Hsp90 alpha Protein, His Tag

产品编号

KMP4071

别名

热休克蛋白90α, Hsp90 alpha Protein, Mouse Hsp90 alpha Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	热休克蛋白90α, Hsp90 alpha Protein, Mouse Hsp90 alpha Protein, His Tag
Catalog Number	KMP4071
Product Description	The Mouse Hsp90 alpha Protein(KMP4071) is produced in Insect Cells. A DNA sequence encoding the Mouse HSP90AA1 (NP_032328.2) (Met1-Asp733) is expressed, with a polyhistidine tag at the N-terminus.
Molecular Name	Hsp90 alpha
Species	Mouse
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM PB, 300mM NaCl, 10% Glycerol, 1mM TCEP, 0.5mM PMSF, pH7.0
Background	Heat shock protein 90 (90 kDa heat-shock protein, HSP90) is a molecular chaperone involved in the trafficking of proteins in the cell. It is a remarkably versatile protein involved in the stress response and normal homoeostatic control mechanisms. HSP90 interacts with 'client proteins', including protein kinases, transcription factors, and others, and either facilitates their stabilization and activation or directs them for proteasomal degradation. By this means, HSP90 displays a multifaceted ability to influence signal transduction, chromatin remodeling and epigenetic regulation, development, and morphological evolution. HSP90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis at the N-terminus. Disruption of HSP90 leads to client protein degradation and often cell death. Under stressful conditions, HSP90 stabilizes its client proteins and protects the cell against cellular stressors such as in cancer cells. Especially, several oncoproteins act as HSP90 client proteins and tumor cells require higher HSP90 activity than normal cells to maintain their malignancy. For this reason, Hsp90 has emerged as a promising target for anti-cancer drug development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	87.19 kDa

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