Mouse OSTM1 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse OSTM1 Protein, His Tag

Mouse OSTM1 Protein, His Tag

产品编号

KMP4070

别名

破骨细胞生成相关跨膜蛋白1, OSTM1 Protein, Mouse OSTM1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	破骨细胞生成相关跨膜蛋白1, OSTM1 Protein, Mouse OSTM1 Protein, His Tag
Catalog Number	KMP4070
Product Description	The Mouse OSTM1 Protein(KMP4070) is produced in HEK293 Cells. A DNA sequence encoding the Mouse Ostm1 (NP_766004.1) (Met1-Ser288) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	OSTM1
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Osteopetrosis-associated transmembrane protein 1 (OSTM1) is a Single-pass type I membrane protein. It is expressed in many hematopoietic cells of the myeloid and lymphoid B- and T-lineages. The analysis of OSTM1 association with CLCN7 demonstrated that OSTM1 requires CLCN7 to localize to lysosomes, whereas the formation of a CLCN7-OSTM1 complex is required to stabilize CLCN7. OSTM1 plays a major role in myelopoiesis and lymphopoiesis and provided evidence of a crosstalk mechanism between hematopoietic cells for osteoclast activation. Thus, OSTM1 has an important role in osteoclast function and activation. The loss of function of OSTM1 results in deregulation of multiple hematopoietic lineages in addition to osteoclast lineage, OSTM1-defect patients display the most severe recessive osteopetrosis phenotype and die at early ages. Furthermore, it is suggested that OSTM1 has a primary role in neural development not related to lysosomal dysfunction. The canonical Wnt/beta-catenin signaling pathway may be a molecular basis for OSTM1 mutations and severe autosomal recessive osteopetrosis (ARO).
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	29.7 kDa

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