Mouse PRKAR1A Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse PRKAR1A Protein, His Tag

Mouse PRKAR1A Protein, His Tag

产品编号

KMP4068

别名

蛋白激酶cAMP依赖性I型调节亚基α, PRKAR1A Protein, Mouse PRKAR1A Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	蛋白激酶cAMP依赖性I型调节亚基α, PRKAR1A Protein, Mouse PRKAR1A Protein, His Tag
Catalog Number	KMP4068
Product Description	The Mouse PRKAR1A Protein(KMP4068) is produced in Insect Cells. A DNA sequence encoding the Mouse PRKAR1A (NP_068680.1) (Met1-Val381) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	PRKAR1A
Species	Mouse
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, pH7.5
Background	PRKAR1A, also known as PRKAR1 and PKR1, is one of the regulatory subunits of cAMP-dependent protein kinase A (PKA). PKA can be activated by cAMP. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating PKA, which transduces the signal throughphosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. PRKAR1A was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids Three alternatively spliced transcript variants encoding the same protein have been observed.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44.6 kDa

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