Mouse B7-H3 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Mouse B7-H3 Protein, hFc Tag

Mouse B7-H3 Protein, hFc Tag

产品编号

KMP3987

别名

共刺激分子蛋白, B7-H3 Protein, Mouse B7-H3 Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	共刺激分子蛋白, B7-H3 Protein, Mouse B7-H3 Protein, hFc Tag
Catalog Number	KMP3987
Product Description	The Mouse B7-H3 Protein(KMP3987) is produced in HEK293 Cells. A DNA sequence encoding the Mouse CD276 (NP_598744.1) (Met1-Phe244) is expressed with the Fc region of human IgG1 at the C-terminus.
Molecular Name	B7-H3
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	B7-H3 is a member of the B7 family of immune regulatory ligands that is thought to attenuate peripheral immune responses through co-inhibition. It plays an important role in adaptive immune responses, and was shown to either promote or inhibit T-cell responses in various experimental systems. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is a novel protein structurally related to the B7 family of ligands by the presence of a single set of immunoglobulin-V-like and immunoglobulin-C-like (VC) domains. Previous studies have correlated its overexpression with poor prognosis and decreased tumor-infiltrating lymphocytes in various carcinomas including uterine endometrioid carcinomas, and mounting evidence supports an immuno-inhibitory role in ovarian cancer prognosis. Recently, B7-H3 expression has been reported in several human cancers indicating an additional function of B7-H3 as a regulator of antitumor immunity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	50.5 kDa

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