Mouse CTHRC1 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse CTHRC1 Protein, His Tag

Mouse CTHRC1 Protein, His Tag

产品编号

KMP3983

别名

胶原三螺旋重复蛋白-1, CTHRC1 Protein, Mouse CTHRC1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	胶原三螺旋重复蛋白-1, CTHRC1 Protein, Mouse CTHRC1 Protein, His Tag
Catalog Number	KMP3983
Product Description	The Mouse CTHRC1 Protein(KMP3983) is produced in HEK293 Cells. A DNA sequence encoding the Mouse CTHRC1 (Q9D1D6) (Met1-Lys245) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	CTHRC1
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	24.53 kDa

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