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Mouse PD-L2 Protein, His Tag

Mouse PD-L2 Protein, His Tag

产品编号

KMP3969

别名

程序性细胞死亡1配体2, PD-L2 Protein, Mouse PD-L2 Protein, His Tag

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias程序性细胞死亡1配体2, PD-L2 Protein, Mouse PD-L2 Protein, His Tag
Catalog NumberKMP3969
Product DescriptionThe Mouse PD-L2 Protein(KMP3969) is produced in HEK293 Cells. A DNA sequence encoding the extracellular domain of Mouse PDCD1LG2 (Q9WUL5) (Met1-Arg219) is expressed, with a C-terminal polyhistidine tag. The purified protein is biotinylated in vitro.
Molecular NamePD-L2
SpeciesMouse
HostHEK293 Cells
Size50ug, 100ug, 200ug
Purity>90% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<1.0 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundProgrammed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight24 kDa

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