Mouse EGFL7 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse EGFL7 Protein, His Tag

Mouse EGFL7 Protein, His Tag

产品编号

KMP3919

别名

EGF样域蛋白7, EGFL7 Protein, Mouse EGFL7 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	EGF样域蛋白7, EGFL7 Protein, Mouse EGFL7 Protein, His Tag
Catalog Number	KMP3919
Product Description	The Mouse EGFL7 Protein(KMP3919) is produced in Insect Cells. A DNA sequence encoding the Mouse EGFL7 isoform 1 (Q9QXT5-1) (Glu 22-Leu 275) is fused with a polyhistidine tag at the N-terminus.
Molecular Name	EGFL7
Species	Mouse
Host	Insect Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	100mM Glycine, 10mM NaCl, 10% Gly, pH7.0
Background	Epidermal growth factor-like protein 7, also known as EGF-like protein 7, Multiple epidermal growth factor-like domains protein 7, Multiple EGF-like domains protein 7, Vascular endothelial statin, NOTCH4-like protein and EGFL7, is a secreted protein which contains twoEGF-like domains and oneEMI domain. EGFL7 was identified by a number of groups as a putative secreted factor produced by the vascular endothelial cells (ECs). EGFL7 is described as a novel endothelial cell-derived factor involved in the regulation of the spatial arrangement of cells during vascular tube assembly. With its impact on tubulogenesis and vessel shape EGFL7 joined the large family of molecules governing blood vessel formation. EGFL7 regulates midline angioblast migration in zebrafish embryos-a key step in vascular tubulogenesis. EGFL7 is tightly associated with the extracellular matrix (ECM), and it supports EC migration either as a single factor or in combination with other ECM molecules. EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning. Our study indicates that the molecular composition of the ECM influences vascular morphogenesis. EGFL7 also regulates vascular tubulogenesis. It inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	29.8 kDa

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