Mouse LDLR Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse LDLR Protein, His Tag

Mouse LDLR Protein, His Tag

产品编号

KMP3882

别名

低密度脂蛋白受体, LDLR Protein, Mouse LDLR Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	低密度脂蛋白受体, LDLR Protein, Mouse LDLR Protein, His Tag
Catalog Number	KMP3882
Product Description	The Mouse LDLR Protein(KMP3882) is produced in HEK293 Cells. A DNA sequence encoding the Mouse LDLR (NP_034830.2) precursor (Met1-Arg790) with substitution of Val 23 and Gly 27 by Ala 23 and Cys 27 respectively is expressed with a C-terminal polyhistidine tag. The purified protein is biotinylated in vitro.
Molecular Name	LDLR
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	LDL Receptor, also known as LDLR, is a mosaic protein that belongs to the Low-density lipoprotein receptor gene family. The low-density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LDL Receptor consists of 840 amino acids (after removal of signal peptide) and mediates the endocytosis of cholesterol-rich LDL. Low-density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. LDL Receptor is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	85.7 kDa

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