Mouse CLEC4F Protein, hFc Tag_天津卡梅德科技发展有限公司

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Mouse CLEC4F Protein, hFc Tag

Mouse CLEC4F Protein, hFc Tag

产品编号

KMP3880

别名

C型凝集素结构域家族4成员F, CLEC4F Protein, Mouse CLEC4F Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	C型凝集素结构域家族4成员F, CLEC4F Protein, Mouse CLEC4F Protein, hFc Tag
Catalog Number	KMP3880
Product Description	The Mouse CLEC4F Protein(KMP3880) is produced in HEK293 Cells. A DNA sequence encoding the Mouse Clec4f (NP_058031.2) (Arg70-Gly548) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name	CLEC4F
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CLEC4F, a member of C-type lectins, was firstly purified from rat liver extract with high binding affinity to fucose, galactose and N-acetylgalactosamine, and un-sialylated glucosphingolipids with GalNAc or Gal terminus. However, the biological functions of CLEC4F have not been elucidated. Histochemical staining showed that mouse CLEC4F(mCLEC4F) is only expressed on F4/8+ cells localized in liver, and is undetectable in bone marrow, spleen, lymph nodes, or other tissues in adult mice. However, mCLEC4F is detected in the liver of embryonic day 11.5 (E11.5), which is 1.5 day earlier than the formation of liver (E1) and is 3.5 day earlier than the formation of bone marrow (E15-16). Moreover, recombinant mCLEC4F.Fc binds to alpha-galactoceramide in a Ca++-dependent manner, and both galactose and ceramide can partially inhibit CLEC4F.Fc binding to alpha-galactoceramide. Interestingly, mCLEC4F-deficient (mCEC4F k/o) mice produced far less cytokines than wild type littermates after intravenous injection ofalpha-galactoceramide. This suggests that mCLEC4F is not only a specific marker for Kupffer cells, but is also critical for the presentation of glycolipid antigen to NKT cells.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	82.1 kDa

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