Mouse BCMA Protein, hFc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Mouse BCMA Protein, hFc Tag, Avi Tag

Mouse BCMA Protein, hFc Tag, Avi Tag

产品编号

KMP3835

别名

B细胞成熟蛋白, BCMA Protein, Mouse BCMA Protein, hFc Tag, Avi Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	B细胞成熟蛋白, BCMA Protein, Mouse BCMA Protein, hFc Tag, Avi Tag
Catalog Number	KMP3835
Product Description	The Mouse BCMA Protein(KMP3835) is produced in HEK293 Cells. A DNA sequence encoding the human TNFRSF17 (NP_035738.1) (Met1-Thr49) is expressed with a c-terminal Fc region of human IgG1 tagged Avi tag at the C-terminus. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	BCMA
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	34 kDa

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