Mouse SFRP1 Protein, His Tag_天津卡梅德科技发展有限公司

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Mouse SFRP1 Protein, His Tag

Mouse SFRP1 Protein, His Tag

产品编号

KMP3820

别名

分泌型卷曲相关蛋白1, SFRP1 Protein, Mouse SFRP1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	分泌型卷曲相关蛋白1, SFRP1 Protein, Mouse SFRP1 Protein, His Tag
Catalog Number	KMP3820
Product Description	The Mouse SFRP1 Protein(KMP3820) is produced in CHO Cells. A DNA sequence encoding the Mouse SFRP1 (AAC53145.1) (Met1-Lys314) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	SFRP1
Species	Mouse
Host	CHO Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Secreted frizzled-related protein 1, also known as sFRP1, is a 35 kDa prototypical member of the SFRP family. SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt signaling, counteracting Wnt-induced effects at high concentrations and promoting them at lower concentrations. SFRPs are able to bind Wnt proteins and Fz receptors in the extracellular compartment. The interaction between SFRPs and Wnt proteins prevents the latter from binding the Fz receptors. The Wnt pathway plays a key role in embryonic development, cell differentiation and cell proliferation. The deregulation of this critical developmental pathway occurs in several human tumor entities. Mouse sFRP1 is highly expressed in kidney and embryonic heart, as well as in the eye, where it is principally localized to the ciliary body and the lens epithelium.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	32.6 kDa

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