Cynomolgus CD33 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD33 Protein, His Tag

Cynomolgus CD33 Protein, His Tag

产品编号

KMP3766

别名

氨基肽酶N, CD33 Protein, Cynomolgus CD33 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	氨基肽酶N, CD33 Protein, Cynomolgus CD33 Protein, His Tag
Catalog Number	KMP3766
Product Description	The Cynomolgus CD33 Protein(KMP3766) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus CD33 (EHH59833.1/EHH30318.1) (Met1-Gly248) is expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus CD33 sequences are identical.
Molecular Name	CD33
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Myeloid cell surface antigen CD33 also known as Sialic acid binding Ig-like lectin 3, CD33 antigen or Siglec-3, is a member of the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. This Single-pass type I membrane protein contains 1 Ig-like C2-type (immunoglobulin-like) domain and 1 Ig-like V-type (immunoglobulin-like) domain. CD33/Siglec-3 is a putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. CD33/Siglec-3 preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. CD33/Siglec-3 induces apoptosis in acute myeloid leukemia (in vitro). CD33/Siglec-3 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	27.3 kDa

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