Cynomolgus CD274 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD274 Protein, His Tag

Cynomolgus CD274 Protein, His Tag

产品编号

KMP3762

别名

程序性死亡蛋白配体-1, CD274 Protein, Cynomolgus CD274 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡蛋白配体-1, CD274 Protein, Cynomolgus CD274 Protein, His Tag
Catalog Number	KMP3762
Product Description	The Cynomolgus CD274 Protein(KMP3762) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus/Rhesus CD274 (XP_015292694.1) (Met1-Thr239) is expressed with a polyhistidine tag at the C-terminus. Cynomolgus and Rhesus CD274 sequences are identical. The purified protein is biotinylated in vitro.
Molecular Name	CD274
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	26.7 kDa

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