Cynomolgus CD200RLa Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus CD200RLa Protein, His Tag

Cynomolgus CD200RLa Protein, His Tag

产品编号

KMP3740

别名

CD200受体1样, CD200RLa Protein, Cynomolgus CD200RLa Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	CD200受体1样, CD200RLa Protein, Cynomolgus CD200RLa Protein, His Tag
Catalog Number	KMP3740
Product Description	The Cynomolgus CD200RLa Protein(KMP3740) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus CD200R1L (XP_005548211.2) (Met1-Ser240) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	CD200RLa
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cell surface glycoprotein CD2 receptor 2, also known as Cell surface glycoprotein CD2 receptor 1-like, Cell surface glycoprotein OX2 receptor 2, CD2 receptor-like 2, CD2Rla, CD2R1L and CD2R2, is a single-pass type I membrane protein which belongs to theCD2R family. CD2R1L/CD2R2. It contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. CD2 is a transmembrane protein delivering immunoregulatory signals after engagement of CD2R. A family of CD2Rs exist ( CD2R1, CD2R2, CD2R3, CD2R4 ) with different tissue expression and functional activity. In the presence of anti-CD2R2/CD2R3 monoclonal antibodies (mAbs), bone-marrow cells cultured in the presence of (interleukin [IL]-4+granulocyte-macrophage colony-stimulating factor) differentiate into dendritic cells (DCs), which induce CD4+CD25+ Treg. Interaction between the relatively ubiquitously expressed molecule CD2 and one of its receptors, CD2R1, resulted in direct suppression of alloreactivity, engagement of alternate receptors led instead to altered differentiation of dendritic cells (DCs) from marrow precursors, which could in turn foster development of Foxp3(+) regulatory T cells. Unlike anti-CD2R1, anti-CD2R2 both promotes development of DCs with capacity to induce Treg and directly augments thymocyte production of Treg.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	25.18 kDa

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