Cynomolgus IL12RB2 Protein, mFc Tag_天津卡梅德科技发展有限公司

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Cynomolgus IL12RB2 Protein, mFc Tag

Cynomolgus IL12RB2 Protein, mFc Tag

产品编号

KMP3739

别名

白细胞介素12受体亚基β2, IL12RB2 Protein, Cynomolgus IL12RB2 Protein, mFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素12受体亚基β2, IL12RB2 Protein, Cynomolgus IL12RB2 Protein, mFc Tag
Catalog Number	KMP3739
Product Description	The Cynomolgus IL12RB2 Protein(KMP3739) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus IL12RB2 (XP_005543136.1) (Lys24-Asn623) is expressed with the Fc region of Mouse IgG2a at the C-terminus.
Molecular Name	IL12RB2
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin-12 receptor subunit beta-2 (IL12RB2), also known as IL-12 receptor subunit beta-2, IL-12R subunit beta-2, IL-12R-beta-2, and IL-12RB2, is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. IL12RB2 belongs to the type I cytokine receptor family. The coexpression of IL12RB2 and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of IL12RB2 is up-regulated by IFN gamma in Th1 cells and plays a role in Th1 cell differentiation. The up-regulation of IL12RB2 is found to be associated with some infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. This subunit is the signaling component coupling to the JAK2/STAT4 pathway. IL12RB2 promotes the proliferation of T-cells as well as NK cells. IL12RB2 induces the promotion of T-cells towards the Th1 phenotype by strongly enhancing IFN-gamma production.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	94.93 kDa

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