Cynomolgus IL12RB1 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus IL12RB1 Protein, His Tag

Cynomolgus IL12RB1 Protein, His Tag

产品编号

KMP3738

别名

白细胞介素12受体亚基β1, IL12RB1 Protein, Cynomolgus IL12RB1 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素12受体亚基β1, IL12RB1 Protein, Cynomolgus IL12RB1 Protein, His Tag
Catalog Number	KMP3738
Product Description	The Cynomolgus IL12RB1 Protein(KMP3738) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus IL12RB1 (XP_015296347.1) (Met1-Asp545) is expressed with a polyhistidine tag at the C-terminus.
Molecular Name	IL12RB1
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Interleukin 12 receptor, beta 1 is also known as IL-12 receptor beta component, IL-12R subunit beta-1, and CD212 antigen (CD212). IL12RB1(CD212) is a subunit of the interleukin 12 receptor. IL12RB1(CD212) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity and is thought to be a part of the IL12 receptor complex. IL12RB1(CD212) forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of IL12RB1 and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. IL12RB1(CD212) Functions as an interleukin receptor that binds interleukin-12 with low affinity and is involved in IL12 transduction. It is associated with IL12RB2 it forms a functional, high-affinity receptor for IL12. IL12RB1(CD212) associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	58.98 kDa

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