Cynomolgus CEACAM5 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Cynomolgus CEACAM5 Protein, hFc Tag

Cynomolgus CEACAM5 Protein, hFc Tag

产品编号

KMP3705

别名

癌胚抗原相关细胞粘附分子5, CEACAM5 Protein, Cynomolgus CEACAM5 Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	癌胚抗原相关细胞粘附分子5, CEACAM5 Protein, Cynomolgus CEACAM5 Protein, hFc Tag
Catalog Number	KMP3705
Product Description	The Cynomolgus CEACAM5 Protein(KMP3705) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus CEACAM5 (XP_005589491.1) (Met1-Ala688) is expressed with the fused Fc region of human IgG1 at the C-terminus.
Molecular Name	CEACAM5
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CEACAM5, also known as CEA or D66e, belongs to the large CEACAM subfamily of the immunoglobulin superfamily. CEACAM5 is expressed primarily by epithelial cells, and is synthesized as a glycoprotein with an MW of 180 kDa comprising 60% carbohydrate. CEACAM5 contains one Ig-like V-type domain at the N-terminus, followed by six Ig-like C2-type domains and a GPI anchor, and exists as a homodimer. CEACAM5 and CEACAM6 are overexpressed in many cancers and are associated with adhesion and invasion. CEACAM5 can mediate cell-cell adhesion through homotypic and heterotypic interactions. It functions as a homotypic intercellular adhesion molecule and serves as a widely used tumor marker, since it is expressed at higher levels in tumorous tissues than in corresponding normal tissues. CEACAM5 has also been shown to contribute to tumorigenicity by inhibiting cellular differentiation. In addition, CEACAM5 is identified as the host receptor for the Dr family of adhesins of E.Coli, and the binding of E.coli Dr adhesins leads to dissociation of the CEACAM5 homodimer.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	98.76 kDa

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