Cynomolgus PD-1 Protein, hFc Tag, Avi Tag_天津卡梅德科技发展有限公司

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Cynomolgus PD-1 Protein, hFc Tag, Avi Tag

Cynomolgus PD-1 Protein, hFc Tag, Avi Tag

产品编号

KMP3685

别名

程序性死亡受体-1, PD-1 Protein, Cynomolgus PD-1 Protein, hFc Tag, Avi Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	程序性死亡受体-1, PD-1 Protein, Cynomolgus PD-1 Protein, hFc Tag, Avi Tag
Catalog Number	KMP3685
Product Description	The Cynomolgus PD-1 Protein(KMP3685) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus PDCD1 (NP_001271065.1) (Met1-Gln167) is expressed with a C-terminal Fc region of human IgG1 tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed.
Molecular Name	PD-1
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Programmed cell death 1, also known as PDCD1, is a type I transmembrane glycoprotein, and is an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signaling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. Furthermore, PD1 is shown to be a regulator of virus-specific CD8+ T cell survival in HIV infection. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	44.5 kDa

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