Cynomolgus ENPP2 Protein, His Tag_天津卡梅德科技发展有限公司

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Cynomolgus ENPP2 Protein, His Tag

Cynomolgus ENPP2 Protein, His Tag

产品编号

KMP3670

别名

外核苷酸焦磷酸酶/磷酸二酯酶2, ENPP2 Protein, Cynomolgus ENPP2 Protein, His Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	外核苷酸焦磷酸酶/磷酸二酯酶2, ENPP2 Protein, Cynomolgus ENPP2 Protein, His Tag
Catalog Number	KMP3670
Product Description	The Cynomolgus ENPP2 Protein(KMP3670) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus ENPP2 (XP_005564040.1) (Asp49-Ile863) is expressed with a polyhistidine tag at the N-terminus.
Molecular Name	ENPP2
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>85% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	ENPP2 (Ectonucleotide pyrophosphatase/phosphodiesterase family member 2), also referred as Autotaxin, is a secreted enzyme encoded by the ENPP2 gene. This gene product stimulates the motility of tumor cells, has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The Autotaxin protein is important for generating the lipid signaling molecule lysophosphatidic acid (LPA), which is a potent mitogen, which facilitates cell proliferation and migration, neurite retraction, platelet aggregation, smooth muscle contraction, actin stress formation and cytokine and chemokine secretion. ATX has been found to catalyze the formation of cyclic phosphatidic acid (cPA), which have antitumor role by antimitogenic regulation of cell cycle, inhibition of cancer invasion and metastasis. LPA receptors and ATX are upregulated in numerous cancer cell types and show expression patterns that correlate with tumor cell invasiveness. Thus, Autotaxin has recently emerged as an attractive target for the development of anti-cancer chemotherapeutics. In addition, Serum ATX activity was found to be enhanced in relation to hepatic fibrosis in chronic liver disease due to hepatitis virus C infection.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	96 kDa

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