Cynomolgus Angiopoietin-1 Protein, hFc Tag_天津卡梅德科技发展有限公司

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Cynomolgus Angiopoietin-1 Protein, hFc Tag

Cynomolgus Angiopoietin-1 Protein, hFc Tag

产品编号

KMP3649

别名

血管生成素1, Angiopoietin-1 Protein, Cynomolgus Angiopoietin-1 Protein, hFc Tag

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	血管生成素1, Angiopoietin-1 Protein, Cynomolgus Angiopoietin-1 Protein, hFc Tag
Catalog Number	KMP3649
Product Description	The Cynomolgus Angiopoietin-1 Protein(KMP3649) is produced in HEK293 Cells. A DNA sequence encoding the Cynomolgus ANGPT1 (XP_005563980.1) (Arg277-Phe498) is expressed with the Fc region of human IgG1 at the N-terminus.
Molecular Name	Angiopoietin-1
Species	Cynomolgus
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, 10% Glycerol, 4% Trehalose, pH7.4
Background	The angiopoietin (ANGPT)-TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. In disease, ANGPT2-mediated inhibition of TIE2 in blood vessels is linked to vascular leak, inflammation, and metastasis. Primary congenital glaucoma (PCG) is a leading cause of blindness in children worldwide and is caused by developmental defects in 2 aqueous humor outflow structures, Schlemm's canal (SC) and the trabecular meshwork. We previously identified loss-of-function mutations in the angiopoietin (ANGPT) receptor TEK in families with PCG and showed that ANGPT/TEK signaling is essential for SC development. A role for the major ANGPT ligands in the development of the aqueous outflow pathway. We determined that ANGPT1 is essential for SC development, and that Angpt1-knockout mice form a severely hypomorphic canal with elevated intraocular pressure. By linking ANGPT1 with PCG, these results highlight the importance of ANGPT/TEK signaling in glaucoma pathogenesis and identify a candidate target for therapeutic development.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	54.1 kDa

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