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Human IL-15 Protein

Human IL-15 Protein

产品编号

KMP3571

别名

白细胞介素-15, Human IL-15 Protein, IL-15

规格
  • 50ug
  • 100ug
  • 200ug
产品介绍
Alias白细胞介素-15, Human IL-15 Protein, IL-15
Catalog NumberKMP3571
Product DescriptionThe Human IL-15 Protein(KMP3571) is produced in E. coli. The target gene encoding the human IL15 (NP_000576.1) (Asn49-Ser162) is expressed.
Molecular NameIL-15
SpeciesHuman
HostE. coli
Size50ug, 100ug, 200ug
Purity>95% as determined by SDS-PAGE
PurificationAffinity purification
Endotoxin<0.01 EU/ug determined by the LAL method
FormulationPBS, pH7.4
BackgroundThe protein encoded by the IL15 gene is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukine 2 share many biological activities. They are found to bind common hematopoietic receptor subunits and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Studies of the mouse counterpart suggested that this cytokine may increase the expression of apoptosis inhibitor BCL2L1/BCL-x(L), possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. Alternatively, spliced transcript variants of this gene have been reported.
Storage ConditionAliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping ConditionIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight12.91 kDa

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