Human IL-35 Protein, Fc-Flag Tag, Fc-His Tag_天津卡梅德科技发展有限公司

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Human IL-35 Protein, Fc-Flag Tag, Fc-His Tag

Human IL-35 Protein, Fc-Flag Tag, Fc-His Tag

产品编号

KMP3559

别名

白细胞介素35, Human IL-35 Protein, Fc-Flag Tag, Fc-His Tag, IL-35

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	白细胞介素35, Human IL-35 Protein, Fc-Flag Tag, Fc-His Tag, IL-35
Catalog Number	KMP3559
Product Description	The Human IL-35 Protein(KMP3559) is produced in HEK293 Cells. The target gene encoding the p35 subunit of human IL12, termed as IL12A (P29459-1) (Met1-Ser219) is fused with a C-terminal Fc region of human IgG1 tag followed by a FLAG tag, constructed the plasmid 1; The target gene encoding the human IL27B (NP_005746.2) (Met1-Lys229) is fused with a C-terminal Fc region of human IgG1 tag followed by a polyhistidine tag, constructed the plasmid 2. The two plasmids are co-expressed and the heterodimer is purified.
Molecular Name	IL-35
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>90% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	IL12A is a subunit of a cytokine that acts on T and natural killer cells and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. IL12A, together with IL27B, form a disulfide-linked heterodimer: IL12A&IL27B. IL12A&IL27B is required for the T-cell-independent induction of IFN-gamma and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of IL12A&IL27B in innate immunity.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	102.1 kDa

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