Human Integrin alpha V beta 8 Protein, His Tag_天津卡梅德科技发展有限公司

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Human Integrin alpha V beta 8 Protein, His Tag

Human Integrin alpha V beta 8 Protein, His Tag

产品编号

KMP3558

别名

整合素α-v/β-8复合体, Human Integrin alpha V beta 8 Protein, His Tag, Integrin alpha V beta 8

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Alias	整合素α-v/β-8复合体, Human Integrin alpha V beta 8 Protein, His Tag, Integrin alpha V beta 8
Catalog Number	KMP3558
Product Description	The Human Integrin alpha V beta 8 Protein(KMP3558) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Val992) of human ITGAV (P06756) is fused with a C-terminal polyhistidine tag is expressed., constructed the plasmid 1; The target gene encoding the extracellular domain (Met1-Arg684) of human ITGB8 (P26012) constructed the plasmid 2. The two plasmids are co-expressed and the human ITGAV&ITGB8 heterodimer is purified.
Molecular Name	Integrin alpha V beta 8
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Integrin alpha V beta 8 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. ITGAVB8 does not appear to assume different activation states; and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif; including vitronectin; fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP; which releases active TGF-beta. This mechanism differs from that of alpha V beta 6; the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Molecular Weight	187.95 kDa

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